In a similar group of patients, the ongoing CAROLINA study is assessing the CV safety of linaglitin compared to â¦ For a clinician who works to achieve optimal outcomes, glucose-lowering therapies form part of a multifactorial intervention package. Importance Type 2 diabetes is associated with increased cardiovascular (CV) risk. CARMELINA (The Cardiovascular and Renal Microvascular Outcome Study With Linagliptin) was designed to evaluate the cardiovascular safety and kidney outcomes of linagliptin, a highly selective DPP-4 inhibitor with minimal renal excretion, 15 in people with T2DM at high cardiovascular and renal risk. Cardiovasc Diabetol. The ongoing CARMELINA trial is examining the CV and renal safety of linagliptin in diabetic patients with high CV risk as compared to placebo. Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA(®)): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk. Currently, 4 large cardiovascular outcome trials have established the cardiovascular safety of DPP-4 inhibitors vs placebo in patients with type 2 diabetes at a high cardiovascular risk, 20-23 including the Cardiovascular and Renal Microvascular Outcome Study with Linagliptin (CARMELINA). The CARMELINA trial was a long-term clinical study of the dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin in patients with type 2 diabetes that conï¬rmed the noninferiority of linagliptin plus standard of care (SoC) versus SoC for 3-point major adverse cardiovascular events. Linagliptin (CARMELINA) was designed to evaluate the CV safety and kidney outcomes of linagliptin in patients with type 2 diabetes at high cardiorenal risk. with LINAgliptin (CARMELINA®):andomized, double-blind,ebo -controlled clinical trial in patients with t2es and high cardio-renal risk Julio Rosenstock1*,Vlado Perkovic 2,John H. Alexander3,Mark E. Cooper4,Nikolaus Marx5,Michael J. Pencina3, Participants in CANVAS were randomly assigned in a 1:1:1 ratio to receive cana - â¦ Randomized, double-blind, placebo-controlled, multicenter noninferiority trial conducted at 605 clinic sites in 27 countries, enrolling adults with type 2 diabetes and HbA 1c 6.5-10.0%. Camelina grows rapidly and, in Montana field trials, completed its lifecycle a few weeks sooner than spring wheat. Design, setting, and participants: Randomized, double-blind, active-controlled, noninferiority trial, with participant screening from November 2010 to December 2012, conducted at 607 hospital and primary care sites in 43 countries involving 6042 participants. Good yields have been achieved following cereal crops on fields which would otherwise have been fallow. The top-line results of the CAROLINA trial indicate that linagliptin is non-inferior to glimepiride. 2018 Mar 14;17(1):39. doi: 10.1186/s12933-018-0682-3. 646 n engl j med 377;7 nejm.orgAugust 17, 2017 The new england journal of medicine by the trial sponsor. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease.
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